(E)-4-Chloro-4-oxo-2-butenoic acid ethyl ester

(E)-4-Chloro-4-oxo-2-butenoic acid ethyl ester - Names and Identifiers

Name	3-Chlorocarbonylacrylic acid ethyl ester
Synonyms	ethyl fumaryl Ethyl fumaryl chloride ethyl (E)-4-chloro-4-oxobut-2-enoate (E)-Ethyl 4-chloro-4-oxobut-2-enoate ethyl (2E)-4-chloro-4-oxobut-2-enoate 3-Chlorocarbonylacrilicacid ethylester 3-Chlorocarbonylacrylic acid ethyl ester (e)-4-chloro-4-oxo-2-butenoic acid ethyl ester (E)-4-Chloro-4-oxo-2-butenoic acid ethyl ester
CAS	26367-48-6
EINECS	200-258-5
InChI	InChI=1/C6H7ClO3/c1-2-10-6(9)4-3-5(7)8/h3-4H,2H2,1H3/b4-3+

(E)-4-Chloro-4-oxo-2-butenoic acid ethyl ester - Physico-chemical Properties

Molecular Formula	C6H7ClO3
Molar Mass	162.57
Density	1.220
Melting Point	16 °C
Boling Point	218°C
Flash Point	93°C
Vapor Presure	0.131mmHg at 25°C
Storage Condition	Room Temprature
Refractive Index	n20/D1.463

(E)-4-Chloro-4-oxo-2-butenoic acid ethyl ester - Risk and Safety

Hazard Symbols	C - Corrosive
Risk Codes	R22 - Harmful if swallowed R34 - Causes burns R43 - May cause sensitization by skin contact
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 3265 8 / PGII
WGK Germany	3

(E)-4-Chloro-4-oxo-2-butenoic acid ethyl ester - Introduction

3-Chlorocarbonylacrylic acid ester is an organic compound with the chemical formula C6H7ClO3. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: colorless liquid
-Melting point:-25 ° C
-Boiling point: 183-185 ° C
-Density: 1.301g/cm³
-Solubility: Soluble in organic solvents such as alcohols, ethers and ketones
-Stability: stable at room temperature, but may decompose under sunlight

Use:
3-Chlorocarbonylacrylic acid ethyl ester is widely used in organic synthesis:
-as an important intermediate of quinoline acylhydrazone antibiotics
-for the synthesis of organic compounds such as pesticides, dyes and pharmaceuticals
-as a crosslinker and additive in coatings
-Monomer used as finishing material

Method:
The preparation of 3-Chlorocarbonylacrylic acid ethyl ester can be carried out by the following steps:
1. Reaction of monoethyl fumarate with acid chloride to generate 3-Chlorocarbonylacrylic acid ethyl ester.
2. The reaction mixture was separated and purified to obtain pure 3-Chlorocarbonylacrylic acid ethyl ester.

Safety Information:
- 3-Chlorocarbonylacrylic acid ethyl ester is a chemical in organic synthesis, and appropriate safety measures should be taken when handling and using.
-It is an irritating chemical that may cause irritation to the eyes, skin and respiratory tract.
-Wear appropriate protective equipment such as gloves, goggles and face shields during use.
-Avoid inhaling its vapors and avoid contact with skin and eyes. If contact occurs, rinse immediately with plenty of water and seek medical help.
-Keep away from ignition and oxidizing agents during storage and handling.

Last Update：2024-04-09 15:17:56